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A Proteoliposome-Based Efflux Assay to Determine Single-molecule Properties of Cl- Channels and Transporters
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Molecular characterization of a broad selectivity neutral solute channel

H Tsukaguchi1, C Shayakul, U V Berger

  • 1Renal Division, Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.

The Journal of Biological Chemistry
|September 12, 1998
PubMed
Summary

Researchers discovered a new liver protein, aquaporin 9 (AQP9), that transports both water and various solutes across cell membranes. This promiscuous channel protein facilitates metabolite exchange while maintaining osmotic balance, challenging previous concepts of solute and water transport.

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