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Updated: Jun 29, 2026

Peptide-based Identification of Functional Motifs and their Binding Partners
Published on: July 1, 2013
HIV infection and AIDS
1Department of Pediatrics, Baylor College of Medicine, Houston, Texas.
Abstract:
The entry of one HIV virion into a human being has the potential to cause death by the inexorable replication of the virus within the principal T lymphocyte, the CD4+ T cell. Although combination antiretroviral therapy, particularly therapy with protease inhibitors, decreases the viral burden to very low, even undetectable, levels, sequestration of the virus in privileged sites, including a long-lived CD4+ T cell, has frustrated efforts at eradication of HIV. Activation of the immune system, therefore, appears essential before this infection can be conquered. Powerful vaccines capable of preventing infection remain the hope of the world.
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