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Developmental stability and signalling among cells

A P Møller1, M Pagel

  • 1Laboratoire d'Ecologie, CNRS URA 258, Université Pierre et Marie Curie, Paris, France.

Journal of Theoretical Biology
|September 15, 1998
PubMed
Summary
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Stable phenotypes rely on cellular selection mechanisms that regulate cell group averages and variations. These stability-selection processes are crucial for overall organ performance and development.

Area of Science:

  • Developmental biology
  • Evolutionary biology
  • Cell biology

Background:

  • Stable phenotypes are essential for organismal development and function.
  • Somatic cellular selection plays a critical role from early developmental stages.
  • Inter-cellular communication signals can influence cellular phenotypes and selection processes.

Purpose of the Study:

  • To investigate the role of inter-cellular selection mechanisms in achieving stable phenotypes.
  • To model the impact of "quality-selection" and "stability-selection" on developmental outcomes.
  • To explore how cellular signaling contributes to developmental selection and phenotypic stability.

Main Methods:

  • Development of an optimality model to simulate inter-cellular selection.

Related Experiment Videos

  • Analysis of "quality-selection" and "stability-selection" mechanisms.
  • Evaluation of the impact of variance in cell phenotypes on organ and body performance.

    • Main Results:

    • Stable phenotypes necessitate significant investment in both quality-selection and stability-selection.
    • Stability-selection mechanisms can have a stronger influence on overall performance than quality-selection.
    • Reliable inter-cellular signaling of phenotypic properties is key to constraining cell phenotype variance.

    Conclusions:

    • Developmentally-selected systems, emphasizing stability-selection, offer advantages over instructional systems.
    • High investment in stability mechanisms promotes homogeneous cell collections, leading to stable organ systems and phenotypes.
    • Environmental and genetic factors, alongside selection modes, influence developmental stability and somatic selection.