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Cerebral blood flow changes in cluster headache

J W Norris, V C Hachinski, P W Cooper

    Acta Neurologica Scandinavica
    |October 1, 1976
    PubMed
    Summary
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    This study monitored cerebral blood flow during a cluster headache. Findings suggest elevated blood flow during the headache, which normalized after treatment with ergotamine tartrate.

    Area of Science:

    • Neurology
    • Neuroimaging
    • Cerebrovascular Physiology

    Background:

    • Cluster headaches are severe neurological conditions characterized by unilateral head pain.
    • Understanding the cerebrovascular changes during a cluster headache is crucial for effective treatment strategies.

    Observation:

    • Serial cerebral blood flow (CBF) measurements were conducted using the intra-carotid 133Xenon method in a patient experiencing a cluster headache.
    • Initial CBF values were at the upper limit of normal, with normal autoregulatory response to hyperventilation.
    • After intramuscular administration of ergotamine tartrate, partial headache relief was observed, accompanied by abnormally high CBF values.

    Findings:

    • Cerebral blood flow was elevated during the cluster headache episode.
    • Autoregulation of cerebral blood flow remained functional during the early stages of the headache.

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  • Ergotamine tartrate treatment, while providing partial relief, was associated with a further increase in cerebral blood flow.

    • Implications:

    • These findings suggest a potential role for altered cerebral hemodynamics in the pathophysiology of cluster headaches.
    • The paradoxical increase in CBF post-treatment warrants further investigation into the mechanisms of ergotamine tartrate in cluster headache.
    • Further research is needed to elucidate the complex interplay between cluster headache, cerebral blood flow, and therapeutic interventions.