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The intestinal ecosystem in chronic functional constipation

G Zoppi1, M Cinquetti, A Luciano

  • 1Department of Paediatrics, Ospedale Civile Maggiore, University of Verona, Italy.

Acta Paediatrica (Oslo, Norway : 1992)
|September 15, 1998
PubMed
Summary
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Children with chronic functional constipation show altered gut bacteria, specifically increased clostridia and bifidobacteria. Calcium polycarbophil did not significantly improve constipation or alter the intestinal ecosystem in this study.

Area of Science:

  • Microbiology
  • Pediatrics
  • Gastroenterology

Background:

  • Chronic functional constipation is a prevalent condition in infants.
  • The intestinal bacterial composition in constipated infants is not well understood.

Purpose of the Study:

  • To investigate the intestinal ecosystem composition in children with chronic functional constipation.
  • To assess the efficacy of calcium polycarbophil in improving constipation.
  • To determine the impact of calcium polycarbophil on the intestinal ecosystem.

Main Methods:

  • A double-blind, randomized study involving 42 children with chronic functional constipation and 14 healthy controls.
  • Faecal samples were analyzed using microbiological and biochemical methods before and after a 1-month treatment period.

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  • Children received either oral calcium polycarbophil or a placebo.

    • Main Results:

    • Constipated children exhibited a significant increase in clostridia and bifidobacteria compared to healthy controls, indicating a dysbiosis.
    • Calcium polycarbophil treatment resulted in clinical resolution in 43% and improvement in 21% of children.
    • No significant changes in the intestinal ecosystem or blood chemistry were observed following calcium polycarbophil treatment.

    Conclusions:

    • Children with chronic functional constipation present with a distinct gut bacterial dysbiosis.
    • Calcium polycarbophil shows limited efficacy in treating chronic functional constipation in children.
    • The water-holding agent calcium polycarbophil does not alter the intestinal microbial composition.