Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Prostaglandins in macula densa function

R C Harris1, J L Wang, H F Cheng

  • 1George M. O'Brien Kidney and Urologic Diseases Center and Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA. Ray.Harris@mcmail.vanderbilt.edu

Kidney International. Supplement
|September 15, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Characterization of titanium dioxide and zinc oxide nanoparticles in sunscreen powder by comparing different measurement methods.

Journal of food and drug analysis·2018
Same author

[Impact of maternal risky behaviors on the behaviors of children born to adolescent and young mothers].

Zhonghua er ke za zhi = Chinese journal of pediatrics·2018
Same author

Development of an indirect ELISA for bovine mastitis using Sip protein of Streptococcus agalactiae.

Iranian journal of veterinary research·2016
Same author

Tunnel electroresistance through organic ferroelectrics.

Nature communications·2016
Same author

[Stress distribution and deformation of uterosacral ligament and cardinal ligament under different working conditions simulated by the finite element model].

Zhonghua fu chan ke za zhi·2016
Same author

Depression and risk of type 2 diabetes: the potential role of metabolic factors.

Molecular psychiatry·2016
Same journal

Effect of kidney disease on glucose handling (including genetic defects).

Kidney international. Supplement·2011
Same journal

Need for better diabetes treatment for improved renal outcome.

Kidney international. Supplement·2011
Same journal

Glucose dynamics and mechanistic implications of SGLT2 inhibitors in animals and humans.

Kidney international. Supplement·2011
Same journal

SGLT2 inhibitors: molecular design and potential differences in effect.

Kidney international. Supplement·2011
Same journal

Glucose handling by the kidney.

Kidney international. Supplement·2011
Same journal

Bone: from a reservoir of minerals to a regulator of energy metabolism.

Kidney international. Supplement·2011
See all related articles

Cyclooxygenase-2 (COX-2) in the kidney plays a role in regulating renin release. Further research is needed to understand how COX-2 inhibitors affect the renin-angiotensin system and kidney function.

Area of Science:

  • Nephrology
  • Renal Physiology
  • Molecular Biology

Background:

  • Cyclooxygenase-2 (COX-2) is found in the macula densa and thick ascending limb of the renal cortex.
  • Chronic sodium chloride restriction elevates COX-2 expression in the kidney.

Purpose of the Study:

  • To investigate the role of macula densa-associated COX-2 in mediating renin release.
  • To explore the potential impact of selective COX-2 inhibitors on the renin-angiotensin system and glomerular hemodynamics.

Main Methods:

  • Localization of COX-2 mRNA and protein in renal cortex.
  • Assessment of COX-2 expression under conditions of chronic NaCl restriction.

Main Results:

  • COX-2 expression was observed in the macula densa and adjacent cortical thick ascending limb.

Related Experiment Videos

  • Increased COX-2 expression was noted with chronic NaCl restriction.

    • Conclusions:

    • Eicosanoids generated by macula densa-associated COX-2 are likely involved in regulating renin release.
    • The effects of selective COX-2 inhibitors on renal function warrant further investigation.