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Antimalarial activities of polyhydroxyphenyl and hydroxamic acid derivatives
K P Holland1, H L Elford, V Bracchi
1Interdisciplinary Center for Biotechnology Research, University of Florida, Gainesville, Florida 32611, USA.
Antimicrobial Agents and Chemotherapy
|September 16, 1998
Abstract:
Several known mammalian ribonucleotide reductase inhibitors featuring a polyhydroxyphenyl and/or hydroxamate moiety as the active group were screened for potency in inhibiting growth of the malaria parasite Plasmodium falciparum. Compounds containing a 2,3- or 3,4-dihydroxyphenyl group as well as benzohydroxamate appear to be the most effective inhibitors of the malaria parasite.