Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Altered cardiovascular variability in obstructive sleep apnea

K Narkiewicz1, N Montano, C Cogliati

  • 1From the Departments of Internal Medicine and Neurology, Cardiovascular Division, University of Iowa, Iowa City, IA 52242, USA.

Circulation
|September 16, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Point of care ultrasound: focus on evidence for a critical appraisal.

European journal of internal medicine·2025
Same author

Anaphylaxis trend before and during pandemic: COVID-19 did not affect anaphylaxis frequency.

European annals of allergy and clinical immunology·2025
Same author

Applications to augment patient care for Internal Medicine specialists: a position paper from the EFIM working group on telemedicine, innovative technologies & digital health.

Frontiers in public health·2024
Same author

The impact of war on the development and progression of arterial hypertension and cardiovascular disease: protocol of a prospective study among Ukrainian female refugees.

Frontiers in cardiovascular medicine·2024
Same author

Phenotyping pleural effusion in patients hospitalized in Internal Medicine wards with decompensated heart failure.

European journal of internal medicine·2023
Same author

Moving forward with point-of-care ultrasound: An (early) educational effort can (also) strengthen research.

European journal of internal medicine·2022
Same journal

Eugene Braunwald, MD, 1929-2026.

Circulation·2026
Same journal

AHA/ACC/ESC/WHF Expert Consensus Document: Second Universal Definition of Heart Failure (2026).

Circulation·2026
Same journal

Advancing Quality in the Evaluation, Surveillance, and Management of Aortic Stenosis: A Report From the AHA Target: AS Registry.

Circulation·2026
Same journal

Heart Failure Occurring in the Perinatal Period: A Scientific Statement From the American Heart Association.

Circulation·2026
Same journal

Correction to: 2026 ACC/AHA/AACVPR/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Dyslipidemia: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.

Circulation·2026
Same journal

Correction to: The Natural History of Massive Left Ventricular Hypertrophy in Pediatric Hypertrophic Cardiomyopathy: A Multiregistry Analysis.

Circulation·2026
See all related articles

Obstructive sleep apnea (OSA) alters cardiovascular variability, even in patients without other diseases. These changes in heart rate and blood pressure variability may increase the risk of future cardiovascular events.

Area of Science:

  • Cardiology
  • Sleep Medicine
  • Autonomic Nervous System Research

Background:

  • Altered cardiovascular variability is a key indicator of future cardiovascular events.
  • Obstructive sleep apnea (OSA) is linked to an increased risk of cardiovascular disease.
  • The study investigates if OSA affects cardiovascular variability independently of other conditions.

Purpose of the Study:

  • To test the hypothesis that obstructive sleep apnea (OSA) is associated with changes in cardiovascular variability.
  • To determine if these alterations are present even without diagnosed cardiovascular disease.

Main Methods:

  • Spectral analysis of muscle sympathetic nerve activity, RR interval, and blood pressure variability.
  • Measurements taken during rest in patients with moderate-to-severe OSA, mild OSA, and healthy controls.

Related Experiment Videos

  • Participants were newly diagnosed, treatment-naive OSA patients without other known diseases.

    • Main Results:

    • Moderate-to-severe OSA patients showed shorter RR intervals and increased sympathetic activity compared to controls.
    • RR interval variability was reduced in moderate-to-severe OSA patients, with altered spectral components.
    • Blood pressure variability was significantly higher in moderate-to-severe OSA patients, correlating with OSA severity.

    Conclusions:

    • Cardiovascular variability is demonstrably altered in patients with obstructive sleep apnea (OSA).
    • These abnormalities are present even in the absence of hypertension or heart failure.
    • The findings suggest that altered cardiovascular variability in OSA may contribute to the development of cardiovascular disease.