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Chronic renal failure: an overview from a pediatric perspective

P Saborio1, S Hahn, S Hisano

  • 1Nephrology Division, Department of Pediatrics and Department of Biochemistry and Molecular Biophysics, Virginia Commonwealth University's Medical College of Virginia, Richmond, Va., USA.

Nephron
|September 16, 1998
PubMed

Insights

Chronic renal failure significantly impacts children, leading to end-stage renal disease. This study details its costs, causes, and uremia complications, summarizing treatment strategies.

Area of Science:

  • Nephrology
  • Pediatric Nephrology
  • Uremia Pathophysiology

Background:

  • Chronic renal failure is a leading cause of end-stage renal disease in children.
  • Understanding the economic and health impacts is crucial for pediatric populations.
  • Uremia presents unique challenges in both pediatric and adult patients.

Purpose of the Study:

  • To present data on the costs and impact of chronic renal failure in children.
  • To identify primary renal diseases leading to end-stage renal disease in pediatric patients.
  • To review adaptive responses, pathophysiology, and complications of uremia.

Main Methods:

  • Data analysis of chronic renal failure costs and impact.
  • Review of pediatric renal diseases causing end-stage renal disease.
  • Literature review on uremia pathophysiology, complications, and adaptive responses in humans and animals.

Main Results:

  • Data on the economic burden and health consequences of pediatric chronic renal failure.
  • Identification of key renal diseases precipitating end-stage renal disease in children.
  • Comprehensive overview of uremia's effects, including adaptive responses and complications.

Conclusions:

  • Chronic renal failure poses significant challenges in pediatric populations.
  • A thorough understanding of uremia is essential for effective management.
  • The study summarizes a potential treatment strategy for chronic renal failure and its complications.

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