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Encapsulation of proteins for improved delivery

S D Putney1

  • 1Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA. sputney@lilly.com

Current Opinion in Chemical Biology
|September 16, 1998
PubMed
Summary

Injectable sustained-release protein formulations are now possible thanks to cryogenic atomization and improved protein stability methods. These advances allow less frequent dosing and may enable new protein drug development.

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Area of Science:

  • Biotechnology
  • Pharmaceutical Sciences
  • Drug Delivery

Background:

  • Clinically useful injectable, sustained-release protein formulations were previously limited.
  • Protein drugs often require frequent administration, impacting patient compliance and cost.
  • Stability of proteins within delivery systems is a significant challenge.

Purpose of the Study:

  • To describe recent advances enabling injectable, sustained-release protein formulations.
  • To highlight the potential benefits of these new formulations for protein drug delivery.
  • To explore the commercial viability of previously undeveloped protein therapeutics.

Main Methods:

  • Development of a nonaqueous, cryogenic atomization process for protein encapsulation.
  • Creation of biodegradable polymer microspheres for controlled protein release.
  • Implementation of strategies to ensure protein stability within microspheres post-injection.

Main Results:

  • Successful encapsulation of proteins into biodegradable microspheres.
  • Demonstrated slow release of proteins from microspheres after injection.
  • Achieved enhanced protein stability within the microspheres for extended durations.

Conclusions:

  • Two key advances facilitate clinically useful, injectable, sustained-release protein formulations.
  • These formulations allow for less frequent administration and potentially lower doses.
  • Sustained-release technology may enable the commercialization of novel protein therapeutics.

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