Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Neuroblastic migration: embryological aspects and mechanisms]

H B Sarnat1

  • 1Departamento de Neurologia, Universidad de Washington, Facultad de Medicina, Seattle 98103, USA. hsarna@chmc.org

Revista De Neurologia
|September 16, 1998
PubMed
Summary

Neuron migration in the cerebrum is genetically programmed, with spindle orientation influencing cell fate and migration readiness. Defects in genes like LIS1 or external factors can disrupt this crucial developmental process.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

New insights into a spectrum of developmental malformations related to mTOR dysregulations: challenges and perspectives.

Journal of anatomy·2019
Same author

Review: The international consensus classification of Focal Cortical Dysplasia - a critical update 2018.

Neuropathology and applied neurobiology·2018
Same author

Neuropathologic research strategies in holoprosencephaly.

Journal of child neurology·2002
Same author

A new classification of malformations of the nervous system: an integration of morphological and molecular genetic criteria as patterns of genetic expression.

European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society·2001
Same author

[A proposal for a molecular genetic classification of the malformations of the nervous system].

Revista de neurologia·2001
Same author

Congenital malformations of the nervous system: a neuropathologic perspective.

Neuroimaging clinics of North America·2001

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Genetics

Context:

  • Cerebral cortex development involves precise neuronal migration.
  • Immature neurons originate from the primitive neuroepithelium.
  • Glial radial cells act as crucial guides for neuronal migration.

Purpose:

  • To elucidate the genetic and cellular mechanisms governing cerebral neuron migration.
  • To understand the role of the LIS1 gene in neuronal positioning.
  • To identify factors contributing to neuronal migration disorders.

Summary:

  • Neuronal migration is a genetically programmed process initiated before the final cell division.
  • The LIS1 gene is expressed in key cells involved in early cortical development.
  • Cell adhesion molecules and glial radial cells are vital for guiding neuroblasts; their deficiency or damage leads to migration defects.

Related Experiment Videos

Impact:

  • Provides insights into the etiology of lissencephaly and other neuronal migration disorders.
  • Highlights the importance of genetic programming and cellular interactions in brain development.
  • Underscores the potential for non-genetic factors to disrupt neurodevelopment.