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Baclofen, a treatment for chronic hiccup
P Walker1, S Watanabe, E Bruera
1Palliative Care Program, Grey Nuns Community Hospital and Health Center, Edmonton, Alberta, Canada.
Journal of Pain and Symptom Management
|September 16, 1998
Summary
Baclofen effectively treats chronic hiccups, as shown in two cases. Gradual discontinuation is advised to prevent withdrawal symptoms like seizures.
Area of Science:
- Neurology
- Pharmacology
Background:
- Hiccups are involuntary contractions of the diaphragm.
- Chronic hiccups can significantly impact quality of life.
Observation:
- Two cases of chronic hiccups were treated.
- The study reviewed current knowledge on hiccups, including definitions, causes, and treatments.
Findings:
- Baclofen demonstrated significant efficacy in treating chronic hiccups.
- Sedation was the most common side effect, with others including insomnia and dizziness.
Implications:
- Baclofen is a promising pharmacologic treatment for chronic hiccups.
- Careful, gradual discontinuation is recommended to avoid potential withdrawal symptoms such as seizures.