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Porphyria cutanea tarda and human immunodeficiency virus: two cases associated with hepatitis C

W J O'Connor1, A D Badley, C H Dicken

  • 1Department of Dermatology, Mayo Clinic Rochester, Minnesota 55905, USA.

Mayo Clinic Proceedings
|September 16, 1998
PubMed

Insights

Hepatitis C virus (HCV) is a likely cause of porphyria cutanea tarda (PCT). Coinfection with HIV and HCV may trigger PCT, necessitating testing for both viruses in affected patients.

Area of Science:

  • Hepatology
  • Virology
  • Dermatology

Background:

  • Porphyria cutanea tarda (PCT) is a metabolic disorder of the skin.
  • Hepatitis C virus (HCV) is increasingly recognized as a potential cause of PCT.
  • Human immunodeficiency virus (HIV) coinfection is common in PCT patients, but HCV status is often unknown.

Observation:

  • Two cases of PCT in patients coinfected with HIV and HCV are presented.
  • The interaction between HIV and HCV in the pathogenesis of PCT is discussed.

Findings:

  • PCT diagnosis, particularly in young individuals, warrants investigation for coexisting HIV and HCV infections.
  • Porphyrin studies are recommended for all HIV-positive patients presenting with photosensitivity.
  • Clinicians must be aware of the potential for infectious transmission from skin lesions in these coinfected patients.

Implications:

  • Early detection of HIV and HCV is crucial for managing PCT.
  • This highlights the importance of screening for viral coinfections in patients with PCT.
  • Understanding viral interactions can improve patient care and prevent disease transmission.

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