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Human diploid cell strains (HDCS) viral vaccines
M A Fletcher1, L Hessel, S A Plotkin
1Pasteur Mérieux Connaught, Marnes La Coquette, France.
Developments in Biological Standardization
|September 16, 1998
Summary
Human diploid cell strain (HDCS) vaccines for polio, rabies, and measles have a proven safety record. Extensive pharmacovigilance shows rare serious events are linked to vaccine viruses, not the HDCS substrate.
Area of Science:
- Vaccinology
- Cell Biology
- Virology
Background:
- Human diploid cell strains (HDCS) were developed in 1961 for virus isolation.
- HDCS have been instrumental in producing numerous licensed human vaccines.
Purpose of the Study:
- To review the safety and efficacy of vaccines derived from human diploid cell strains.
- To assess the long-term safety record of HDCS-derived vaccines through pharmacovigilance.
Main Methods:
- Review of licensed HDCS-derived vaccines including polio, rabies, rubella, measles, varicella-zoster, mumps, and hepatitis A.
- Analysis of pharmacovigilance data spanning over 20 years for these vaccines.
Main Results:
- Multiple HDCS-derived vaccines have been safely used worldwide for decades.
- Serious vaccine-associated events are rare and attributed to vaccine components, not the HDCS.
- Extensive pharmacovigilance confirms a strong safety profile for these vaccines.
Conclusions:
- HDCS-derived vaccines are a safe and effective platform for global immunization.
- There is no credible evidence linking adverse reactions to the HDCS substrate itself.