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Related Experiment Videos

Human studies on polyglycerol polyricinoleate (PGPR)

R Wilson1, M Smith

  • 1Environmental Safety Laboratory, Unilever Research, Sharnbrook, Bedford, UK.

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
|September 16, 1998
PubMed
Summary

Polyglycerol polyricinoleate (PGPR) consumption showed no adverse effects in human volunteers during a 1960s toxicology study. Even at high doses, PGPR did not impact liver, kidney, or biochemical parameters, confirming its safety.

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Area of Science:

  • Food Science
  • Toxicology
  • Human Health

Background:

  • Polyglycerol polyricinoleate (PGPR) is a food additive used as an emulsifier.
  • Early 20th-century food additives required rigorous safety evaluations.
  • Understanding PGPR's human safety profile was crucial for its widespread adoption.

Purpose of the Study:

  • To assess the toxicological effects of PGPR (ADMUL WOL) in human subjects.
  • To determine the impact of PGPR consumption on biochemical parameters and organ function.
  • To establish the safety of PGPR at levels significantly exceeding estimated human intake.

Main Methods:

  • 19 human volunteers consumed up to 10g/day of PGPR for two weeks.
  • Diets were controlled for constant fat and protein levels.

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  • Pre-exposure biochemical parameters were measured, and fat balance tests were conducted.

    • Main Results:

    • Fat balance tests confirmed PGPR digestion and absorption in humans.
    • No consistent adverse effects were observed on biochemical parameters.
    • PGPR showed no toxic effects on liver and kidney function.

    Conclusions:

    • PGPR consumption at high doses (up to 10g/day) produced no adverse effects in human subjects.
    • The study confirmed the safety of PGPR (ADMUL WOL) for human consumption.
    • Findings supported PGPR's safety even at intake levels 63 times higher than estimated daily human exposure.