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[Current hepatitis B epidemiology in Germany]

N Kralj1, F Hofmann, M Michaelis

  • 1Bergische Universität Gesamthochschule Wuppertal.

Gesundheitswesen (Bundesverband Der Arzte Des Offentlichen Gesundheitsdienstes (Germany))
|September 17, 1998
PubMed
Summary
This summary is machine-generated.

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Hepatitis B vaccination significantly reduced infection rates in German healthcare workers. However, the virus spread in non-healthcare roles, highlighting the need for broader vaccination programs to control hepatitis B virus (HBV) spread.

Area of Science:

  • Epidemiology
  • Vaccinology
  • Public Health

Context:

  • Hepatitis B (HB) is a major occupational hazard for healthcare workers (HCWs) and a significant public health concern globally, affecting approximately 350 million individuals.
  • In Germany, 90% of notified HB cases occur in the general population, including high-risk groups.
  • Effective hepatitis B vaccines have been available since 1982, offering a means for disease control.

Purpose:

  • To investigate the epidemiological changes in hepatitis B virus (HBV) infection and carriage among healthcare workers (HCWs) and non-healthcare workers (non-HCWs) at a German university hospital following the introduction of vaccination programs.
  • To assess the effectiveness of plasma-derived and genetically engineered hepatitis B vaccines over a decade (1984-1995).

Summary:

  • Prevalence of anti-HBs/HBc in German HCWs decreased from 12.4% in 1984/85 to 4.4% in 1994/95, becoming comparable to non-HCWs (4.9% to 4.5%).

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  • Conversely, HBV carriage in non-blood contact professions increased from 0.5% to 1.1% during the same period.
  • The study estimates approximately 1.1 million HBV carriers in Germany.

    • Impact:

    • The findings demonstrate the high effectiveness of hepatitis B vaccines in reducing HBV infection among HCWs.
    • The data underscore the necessity of vaccination programs for the general population, aligned with German (STIKO) and WHO recommendations, to control HBV infection nationwide.