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Comparative grepafloxacin phototoxicity in mouse skin
1GlaxoWellcome Research and Development, Ware, Hertfordshire, UK.
The Journal of Antimicrobial Chemotherapy
|September 17, 1998
Summary
Grepafloxacin, a new fluoroquinolone, shows a favorable safety profile regarding phototoxicity compared to other fluoroquinolones. This study found it caused only mild, short-lived skin reactions after ultraviolet exposure.
Area of Science:
- Pharmacology
- Photobiology
- Dermatology
Background:
- Fluoroquinolones are widely used antibiotics.
- Some fluoroquinolones are known to cause phototoxic reactions.
- Assessing phototoxicity is crucial for drug safety.
Purpose of the Study:
- To compare the phototoxic potential of grepafloxacin with marketed fluoroquinolones.
- To evaluate the safety profile of grepafloxacin concerning UV-induced skin reactions.
Main Methods:
- Balb/c mice were administered oral doses of various fluoroquinolones (grepafloxacin, lomefloxacin, sparfloxacin, ofloxacin, ciprofloxacin, enoxacin) or control.
- Mice were exposed to longwave ultraviolet irradiation.
- Phototoxic reactions such as erythema and oedema were assessed over 7 days.
Main Results:
- Lomefloxacin and sparfloxacin induced severe, persistent erythema and oedema.
- Enoxacin caused long-lasting erythema.
- Grepafloxacin, ciprofloxacin, and ofloxacin resulted in mild, transient erythema.
Conclusions:
- Grepafloxacin exhibits a good safety profile concerning phototoxicity.
- The phototoxic potential of grepafloxacin is lower than that of lomefloxacin and sparfloxacin.
- Grepafloxacin is a potentially safer option for respiratory tract infections where phototoxicity is a concern.
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