Related Experiment Videos
Lung cancer patients have increased 8-hydroxydeoxyguanosine levels in peripheral lung tissue DNA
1Department of Environmental Oncology, Institute of Industrial Ecological Sciences, School of Medicine, University of Occupational and Environmental Health, Kitakyushu.
Japanese Journal of Cancer Research : Gann
|September 17, 1998
Abstract:
The 8-hydroxydeoxyguanosine (8-OH-dG) levels in the peripheral parts of human lung tissues were compared between lung cancer patients (n=70) and non-cancer patient controls (n=15). An increased level of 8-OH-dG was observed in the lung cancer group, in both the adenocarcinoma and non-adenocarcinoma (mainly squamous cell carcinoma) groups, as compared to the non-cancer control group. This result suggests that reactive oxygen species are partly involved in the induction of lung carcinomas (both adenocarcinoma and non-adenocarcinoma).