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Interleukin-1 alpha producing synovial sarcoma with prolonged fever: a case report
S Osaka1, Y Fujimoto, H Yamazaki
1Department of Orthopedic Surgery, Nihon University School of Medicine, Tokyo, Japan.
Japanese Journal of Clinical Oncology
|September 18, 1998
Summary
A patient with monophasic fibrous synovial sarcoma experienced prolonged fever, which resolved after tumor removal. Tumor cells expressed interleukin-1 alpha (IL-1 alpha), a cytokine linked to fever, suggesting it caused the patient's symptoms.
Area of Science:
- Oncology
- Immunology
- Pathology
Background:
- Synovial sarcoma is a rare soft tissue sarcoma.
- Prolonged fever can be a challenging clinical symptom with various potential causes.
Observation:
- A patient presented with a monophasic fibrous synovial sarcoma and persistent, spiking fevers.
- Surgical excision of the tumor led to the complete resolution of the fever.
Findings:
- Immunohistochemical analysis revealed interleukin-1 alpha (IL-1 alpha) expression within the sarcoma cells.
- Reverse transcription-polymerase chain reaction (RT-PCR) confirmed the presence of IL-1 alpha cDNA in the tumor, identical to normal human sequences.
- The expressed IL-1 alpha was identified as a potential causative factor for the prolonged fever.
Implications:
- This case suggests that IL-1 alpha produced by sarcoma cells can induce fever.
- Understanding cytokine expression in tumors may offer new insights into paraneoplastic syndromes.
- Targeting IL-1 alpha could be a potential therapeutic strategy for fever associated with certain sarcomas.