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Apolipoprotein E is present in primary localized cutaneous amyloidosis
H Furumoto1, T Shimizu, C Asagami
1Department of Dermatology, Yamaguchi University School of Medicine, Ube, Japan.
The Journal of Investigative Dermatology
|September 18, 1998
Summary
Apolipoprotein E (apoE) is found in primary localized cutaneous amyloidosis, suggesting it plays a role in the disease. This study confirms apoE
Area of Science:
- Dermatology
- Biochemistry
- Pathology
Background:
- Apolipoprotein E (apoE) is linked to Alzheimer's disease and systemic amyloidosis.
- ApoE may act as a "pathologic chaperone," promoting amyloid filament formation.
Purpose of the Study:
- To investigate the association of apoE with amyloid deposits in primary localized cutaneous amyloidosis.
- To determine apoE's role in the etiology of cutaneous amyloidosis.
Main Methods:
- Immunohistochemistry, immunogold electron microscopy, and immunoblotting were used.
- 12 lichen amyloidosus and 1 macular amyloidosis patient samples were analyzed.
Main Results:
- ApoE was detected in amyloid deposits in all examined cases.
- Immunoelectron microscopy confirmed apoE presence on amyloid.
- Immunoblots identified apoE (35K) and a fragment (14K) in amyloid-positive skin.
Conclusions:
- Apolipoprotein E is a component of primary localized cutaneous amyloidosis.
- ApoE likely plays a significant role in the pathogenesis of this condition.