Further clinical evaluation of the selenomethionine uptake test

A review of the selenomethionine uptake ratio as a measure of placental function is presented. Attempts at the early identification of the poorly growing fetus were unsuccessful, and the previously published close correlation of results with clinical findings in later pregnancy has not been confirmed. The theoretical basis of the test has been re-examined. Although modification much reduced the incidence of technically unsatisfactory readings, other difficulties prevented the test from being clinically useful. To some extent the aim of the test has been superseded by concurrent developments and advances in care of the premature baby.