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Dysglycaemia: a cardiovascular risk factor

H C Gerstein1

  • 1Preventive Cardiology and Therapeutics Research Program, Hamilton Civic Hospitals Research Centre, Ontario, Canada. gerstein@fhs.csu.mcmaster.ca

Diabetes Research and Clinical Practice
|September 18, 1998
PubMed
Summary
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High blood sugar (hyperglycemia) is a continuous risk factor for cardiovascular disease, even at non-diabetic levels. Evidence suggests dysglycemia, or raised glucose, increases heart disease risk across a spectrum of glucose control.

Area of Science:

  • Endocrinology
  • Cardiology
  • Epidemiology

Background:

  • Diabetes significantly elevates cardiovascular disease (CVD) risk (2-fold higher than non-diabetics).
  • CVD risk in diabetic patients correlates with the degree of hyperglycemia and glucose control.
  • Emerging evidence links hyperglycemia to CVD risk even in non-diabetic individuals.

Purpose of the Study:

  • To review the evidence linking dysglycemia to cardiovascular disease risk.
  • To explore the continuous nature of glucose levels as a risk factor for CVD.
  • To assess the potential impact of glucose-lowering interventions on CVD prevention.

Main Methods:

  • Systematic review of epidemiologic studies.
  • Analysis of data correlating glucose levels (fasting and postprandial) with CVD incidence.

Related Experiment Videos

  • Comparison of risk factors across diabetic and non-diabetic populations.

    • Main Results:

    • Hyperglycemia is a continuous risk factor for CVD, independent of diabetes status.
    • Even non-diabetic levels of hyperglycemia are associated with increased CVD risk.
    • The relationship between glucose levels and CVD risk is comparable to other established risk factors like smoking and hypertension.

    Conclusions:

    • Dysglycemia, defined as elevated glucose levels above a certain threshold, is a significant and continuous risk factor for cardiovascular disease.
    • This risk extends beyond the diabetic range, impacting individuals with milder forms of hyperglycemia.
    • Further research is needed to determine if glucose-lowering interventions can effectively prevent CVD in both diabetic and non-diabetic populations.