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Buccal prostaglandin E2 for induction of labour
British Journal of Obstetrics and Gynaecology
|September 1, 1976
Summary
Buccal prostaglandin E2 (PGE2) effectively stimulated uterine contractions in 90% of patients. However, unpleasant taste and side effects like nausea and vomiting suggest it offers no advantages over other oxytocic agents.
Area of Science:
- Obstetrics and Gynecology
- Pharmacology
Background:
- Uterine stimulation is crucial for labor induction and augmentation.
- Various oxytocic agents are available, each with specific administration routes and side effect profiles.
Purpose of the Study:
- To evaluate the efficacy and tolerability of buccal prostaglandin E2 (PGE2) for uterine stimulation.
- To compare buccal PGE2 with other methods of administering oxytocic agents.
Main Methods:
- A study involving 30 patients evaluated the administration of buccal prostaglandin E2 (PGE2).
- Patients received a dose of 1 mg hourly.
- Efficacy was measured by uterine stimulation, and side effects were recorded.
Main Results:
- Effective uterine stimulation was observed in 90% of patients.
- Two patients experienced prolonged contractions on a single occasion.
- A high incidence of nausea and vomiting, along with an unpleasant taste, was reported.
Conclusions:
- Buccal PGE2 demonstrates efficacy in stimulating uterine contractions.
- The administration route via buccal tablets is associated with significant tolerability issues.
- Buccal prostaglandins offer no clear advantages over existing oxytocic agents due to side effects.