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Dexfenfluramine in psychotic patients

S Svacina¹, J Sonka, J Marek

¹3rd Medical Clinic, 1st Medical Faculty, Charles University, Prague, Czech Republic.

The International Journal of Eating Disorders

|September 19, 1998

Summary

Dexfenfluramine effectively treated severe overeating in three psychotic patients. This medication managed binge eating without worsening psychiatric symptoms, even in complex cases.

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Area of Science:

Pharmacology
Psychiatry
Endocrinology

Background:

Dexfenfluramine (DF) is contraindicated in patients with severe psychiatric disorders.
Severe overeating can co-occur with chronic psychosis, presenting complex treatment challenges.

Observation:

Three patients with chronic psychosis and severe overeating were treated with dexfenfluramine (DF).
Psychiatric pharmacotherapy remained unchanged during DF administration.
Patients included those with paranoid schizophrenic psychosis and mixed psychosis.

Findings:

Overeating was resolved in all three patients without adverse effects on their psychotic states.
Body weight was maintained by all patients.
Two patients with poorly controlled diabetes showed significant metabolic improvements.
Dosage of up to 75 mg/day was required in one patient during binge eating episodes.

Implications:

Dexfenfluramine (DF) may be a viable treatment for severe overeating in select psychotic patients.
Close psychiatric supervision is crucial when using DF in this population.
Further research is warranted to explore the efficacy and safety of DF in psychotic patients with eating disorders.

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