Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Boundary layer drug delivery using a helical catheter

C P Markou1, J E Brown, M D Pursley

  • 1Department of Medicine, Emory University School of Medicine, Emory University, Atlanta, GA 30322, USA.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|September 19, 1998
PubMed
Summary

A novel helical catheter delivers drugs locally to blood vessel walls, significantly reducing clot formation. This targeted approach enhances antithrombotic and antiproliferative agent efficiency, potentially lowering therapy costs.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Fracture-related hospitalisations in newly diagnosed high-risk localised or metastatic hormone-sensitive prostate cancer: secondary analysis of the STAMPEDE phase III trials of docetaxel and zoledronic acid using healthcare systems data.

Annals of oncology : official journal of the European Society for Medical Oncology·2025
Same author

President's Address at the Iowa and Nebraska Veterinary Medical Association.

The Journal of comparative medicine and veterinary archives·2022
Same author

Angiogenesis, Metabolism, Endothelial and Platelet Markers in Diabetes and Cardiovascular Disease.

British journal of biomedical science·2022
Same author

Landscape distribution and abundance of animal-associated adult filth flies on commercial swine facilities in North Carolina, US.

Medical and veterinary entomology·2021
Same author

Consequences for Norway from a hypothetical accident at the Sellafield reprocessing plant: Atmospheric transport of radionuclides.

Journal of environmental radioactivity·2021
Same author

Management of bone metastasis and cancer treatment-induced bone loss during the COVID-19 pandemic: An international perspective and recommendations.

Journal of bone oncology·2021

Area of Science:

  • Biomedical Engineering
  • Vascular Medicine
  • Drug Delivery Systems

Background:

  • A new catheter-based system for localized endovascular drug delivery has been developed.
  • The helical catheter is designed for percutaneous deployment, with its helical tip placed near the target vascular site for direct contact with the vessel wall.
  • This method aims for efficient delivery of antithrombotic and antiproliferative agents to prevent vascular occlusion, heart attacks, and strokes.

Purpose of the Study:

  • To evaluate the efficacy of a novel helical catheter for local endovascular drug delivery.
  • To demonstrate the catheter's ability to retain infused drugs in the vessel wall boundary layer.
  • To assess the antithrombotic potential of the helical catheter in a preclinical model.

Main Methods:

Related Experiment Videos

  • In vitro evaluation using optical dye density measurements of Evans blue dye under steady flow conditions.
  • In vivo assessment of antithrombotic capacity in a baboon arteriovenous shunt model using a thrombogenic Dacron vascular graft.
  • Administration of Integrelin (glycoprotein IIb/IIIa inhibitor) and hirudin (antithrombin) via the helical catheter.

Main Results:

  • Flow visualization confirmed high concentrations of infused dye retained near the vessel wall.
  • Significant reductions in platelet deposition on the graft surface were observed: 82-97% with Integrelin and 68-92% with hirudin.
  • Local antithrombotic effects were 200-fold (Integrelin) and 30-fold (hirudin) more efficient than systemic administration.

Conclusions:

  • Local drug infusion via the helical catheter achieves high concentrations at target sites.
  • This approach minimizes systemic drug exposure and potential side effects.
  • The method offers potential cost savings through reduced drug requirements.