Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Basic FGF increases communication between cells of the developing neocortex

B Nadarajah1, H Makarenkova, D L Becker

  • 1Department of Anatomy and Developmental Biology, University College London, London WC1E 6BT, United Kingdom.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|September 19, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Role of Myofibroblasts in the Repair of Iatrogenic Preterm Membranes Subjected to Mechanical Stimulation.

Prenatal diagnosis·2024
Same author

Upregulation of epidermal gap junctional proteins in patients with venous disease.

The British journal of surgery·2017
Same author

Abnormal connexin expression in human chronic wounds.

The British journal of dermatology·2015
Same author

Tensile strain increased COX-2 expression and PGE2 release leading to weakening of the human amniotic membrane.

Placenta·2014
Same author

Inhibiting connexin channels protects against cryopreservation-induced cell death in human blood vessels.

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery·2013
Same author

Cost-effectiveness of denosumab in the treatment of postmenopausal osteoporosis in Canada.

Journal of medical economics·2012
Same journal

Vestibular function drives gaze stability in locomoting macaques.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same journal

Region- and layer-specific glutamatergic synapse development in the nascent cortical hierarchy.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same journal

Endogenous peptide derived from c-Cbl-associated protein counteracts its inhibitory effect on enteric neural crest cell colonization in Hirschsprung disease.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same journal

Drowsiness alters the neural dynamics but not the core computations of multisensory integration.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same journal

A Matter of Parameters: Tailored Transcranial Focused Ultrasound Enhances Cortico-Thalamo-Cortical Circuit Resonance.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same journal

Proactive visual and motor prioritization differentially scale with cue reliability.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
See all related articles

Basic fibroblast growth factor (bFGF) increases connexin 43 (Cx43) expression and mRNA in cortical progenitor cells. This suggests bFGF signaling via receptor tyrosine kinases regulates cell proliferation through gap junctions during corticogenesis.

Area of Science:

  • Neuroscience
  • Cell Biology
  • Developmental Biology

Background:

  • Cortical progenitor cells are crucial for brain development.
  • Gap junctions facilitate intercellular communication.
  • Basic fibroblast growth factor (bFGF) is a key signaling molecule.

Purpose of the Study:

  • To investigate the effect of bFGF on gap junction protein expression in cortical progenitor cells.
  • To elucidate the signaling pathways involved in bFGF-mediated changes in Cx43.
  • To understand the functional consequences of bFGF on intercellular communication and proliferation.

Main Methods:

  • In vitro culture of cortical progenitor cells.
  • Quantitative analysis of connexin 43 (Cx43) mRNA and protein expression.

Related Experiment Videos

  • Investigation of receptor tyrosine kinase (RTK) pathway involvement.
  • Assessment of intercellular dye-coupling to measure gap junction function.

    • Main Results:

    • bFGF treatment significantly increased Cx43 expression and mRNA levels in both proliferating and nonproliferating cells.
    • The observed increase in Cx43 is likely due to enhanced gene transcription.
    • bFGF-induced Cx43 upregulation is mediated by the RTK pathway.
    • Enhanced Cx43 expression correlated with increased intercellular dye-coupling via gap junctions.

    Conclusions:

    • bFGF signaling upregulates Cx43 expression in cortical progenitor cells.
    • Gap junction channels play a role in mediating the proliferative effects of bFGF during corticogenesis.
    • This study reveals a novel mechanism by which bFGF influences neural development through gap junction modulation.