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Related Concept Videos

Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Drug toxicity: Drug–Drug Interaction01:30

Drug toxicity: Drug–Drug Interaction

Drug–drug interactions can precipitate toxicity through multiple mechanisms. Absorption interactions alter how drugs enter the body, exemplified when ranitidine increases the absorption of basic drugs, while cholestyramine decreases the levels of propranolol. Protein binding interactions occur when drugs share the same binding sites on plasma proteins. Drugs like aspirin and warfarin, when bound in excess, can lead to increased free drug concentrations, enhancing the potential for...
Drug Therapy01:28

Drug Therapy

The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
Healing II: Complications01:24

Healing II: Complications

Complications during healing arise when tissue repair is altered by local or systemic factors. These changes involve abnormal collagen deposition, altered biomechanics, and reduced vascular supply, impairing restoration of normal structure and function.Loss of FunctionScar tissue differs significantly from the original tissue it replaces. In the skin, fibrosis lacks adnexal structures such as hair follicles, sebaceous glands, and sweat glands. Their absence reduces tactile sensitivity, impairs...

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Phase II study of neoadjuvant therapy with docetaxel, cisplatin, panitumumab, and radiation therapy followed by surgery in patients with locally advanced adenocarcinoma of the distal esophagus (ACOSOG Z4051).

Annals of oncology : official journal of the European Society for Medical Oncology·2018
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Phase II study of neoadjuvant therapy with docetaxel, cisplatin, panitumumab, and radiation therapy followed by surgery in patients with locally advanced adenocarcinoma of the distal esophagus (ACOSOG Z4051).

Annals of oncology : official journal of the European Society for Medical Oncology·2014
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Long-segment, supercharged, pedicled jejunal flap for total esophageal reconstruction.

The Journal of thoracic and cardiovascular surgery·2005
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Induction treatment before surgery for non-small cell lung cancer.

Lung cancer (Amsterdam, Netherlands)·2004
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Resection of advanced thoracic malignancies requiring cardiopulmonary bypass.

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery·2002
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Oncodiagnosis panel: 1999. Cancer of the lung: oncodiagnosis.

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Related Experiment Video

Updated: Jul 17, 2026

Dual-phase Cone-beam Computed Tomography to See, Reach, and Treat Hepatocellular Carcinoma during Drug-eluting Beads Transarterial Chemo-embolization
09:49

Dual-phase Cone-beam Computed Tomography to See, Reach, and Treat Hepatocellular Carcinoma during Drug-eluting Beads Transarterial Chemo-embolization

Published on: December 3, 2013

Complications of multimodality therapy

J B Putnam1

  • 1Department of Thoracic and Cardiovascular Surgery, University of Texas M.D. Anderson Cancer Center, Houston, USA. putnam@notes.mdacc.tmc.edu

Chest Surgery Clinics of North America
|September 22, 1998
PubMed
Summary

Multimodality therapy can increase complications, but prospective trials for advanced tumors may reduce risks. Careful consideration is needed to balance benefits and potential adverse events in cancer treatment.

Area of Science:

  • Oncology
  • Clinical Trials
  • Treatment Complications

Background:

  • Multimodality therapy, combining different treatment types, may increase treatment-related complications.
  • Such complex treatment regimens are often necessary for advanced or biologically aggressive tumors.

Purpose of the Study:

  • To evaluate the impact of prospective trials on managing treatment-related complications in patients receiving multimodality therapy.
  • To provide insights into optimizing cancer treatment strategies for complex cases.

Main Methods:

  • Analysis of data from patients enrolled in prospective trials involving multimodality therapy.
  • Assessment of treatment-related complications in relation to trial participation.

Main Results:

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  • Information gathered from prospective trials may help mitigate current and future treatment-related complications.
  • Ad hoc, non-trial-based use of multimodality therapies is generally not advised due to potential risks.

Conclusions:

  • Prospective trials are crucial for safely managing multimodality therapy in advanced cancers.
  • Evidence-based approaches through trials can reduce complications and improve patient outcomes.