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[Carbohydrate chains and hematogenous metastasis: a review]
1Department of Surgical Oncology, University of Tokyo School of Medicine, Japan.
Nihon Geka Gakkai Zasshi
|September 22, 1998
Summary
Altered cell surface carbohydrate chains, like sialyl Lewis a (CA 19.9), are linked to cancer progression and metastasis. Their exact role in hematogenous spread remains debated, impacting advanced cancer treatment strategies.
Area of Science:
- Biochemistry
- Oncology
- Cell Biology
Context:
- Cell surface carbohydrate expression is altered during carcinoma development and progression.
- Certain carbohydrate chains function as tumor markers and adhesion molecules.
- The role of these molecules in hematogenous metastasis is still under investigation.
Purpose:
- To review investigations on the role of carbohydrate chains in hematogenous metastasis.
- To discuss the clinical application of carbohydrate chains in advanced cancer treatment.
Summary:
- Carbohydrate chains on cell surfaces change during cancer development.
- Sialyl Lewis a (CA 19.9), sialyl Lewis X, and Tn are implicated as adhesion molecules.
- This review examines their controversial role in metastasis and mentions clinical trials.
Impact:
- Provides a comprehensive overview of carbohydrate chain involvement in cancer metastasis.
- Highlights ongoing research and clinical applications for advanced cancer therapy.
- Contributes to understanding tumor markers and adhesion molecules in oncology.