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Updated: Jul 27, 2026
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In vivo Liver Endocytosis Followed by Purification of Liver Cells by Liver Perfusion
Published on: November 10, 2011
[Effect of enkephalins on the liver secretory function]
T V Masiuk1, S P Vesel'skiĭ, A I Masiuk
1Institute of Physiology of the Kiev University, Ukraine.
Rossiiskii Fiziologicheskii Zhurnal Imeni I.M. Sechenova
|September 22, 1998
Summary
Enkephalin infusion into the portal vein reduces bile flow and secretion of bile acids, proteins, and lipids. These changes in bile secretion are linked to enkephalin
Area of Science:
- Hepatobiliary physiology
- Gastroenterology
- Neuroendocrinology
Background:
- Bile secretion is crucial for digestion and detoxification.
- Enkephalins are endogenous opioid peptides with diverse physiological roles.
- The impact of enkephalins on bile secretion requires further elucidation.
Purpose of the Study:
- To investigate the effects of enkephalin infusion on bile flow and composition.
- To explore the underlying mechanisms of enkephalin-induced changes in bile secretion.
Main Methods:
- Infusion of enkephalins into the portal vein of experimental models.
- Measurement of bile flow rate.
- Analysis of bile acid, protein, and lipid concentrations.
Main Results:
- A significant decrease in bile flow was observed following enkephalin administration.
- Reduced secretion of bile acids, proteins, and lipids into bile was detected.
- Evidence suggests enkephalin influences hepatocyte metabolic processes.
Conclusions:
- Enkephalin infusion negatively impacts bile secretion.
- Metabolic alterations in hepatocytes are likely responsible for these observed effects.
- Further research into neuro-gastrointestinal interactions is warranted.
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