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EEG changes in tuberculous meningitis: a clinicoradiological correlation
1Department of Neurology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.
Electroencephalography and Clinical Neurophysiology
|September 22, 1998
Summary
Electroencephalography (EEG) changes in tubercular meningitis (TBM) correlate with disease severity and patient outcomes. Abnormal EEG findings, including theta-delta slowing, predict poorer prognosis in TBM patients.
Area of Science:
- Neurology
- Infectious Diseases
Background:
- Tubercular meningitis (TBM) is a severe form of meningitis with significant morbidity and mortality.
- Electroencephalography (EEG) is a valuable tool for assessing brain dysfunction.
Purpose of the Study:
- To describe electroencephalographic (EEG) changes in patients with tubercular meningitis (TBM).
- To correlate EEG findings with clinical and radiological findings in TBM.
- To assess the relationship between EEG abnormalities and patient outcomes.
Main Methods:
- Thirty-two patients with probable or definite TBM underwent neurological evaluation, CSF analysis, EEG, and CT scans.
- Patient outcomes were assessed at 3 months using the Barthel index (BI).
- EEG abnormalities analyzed included diffuse slowing, intermittent rhythmic delta activity, asymmetry, and epileptiform discharges.
Main Results:
- EEG was abnormal in 24 patients, with diffuse theta-delta slowing being the most common finding (22 patients).
- CT scan abnormalities were observed in 22 patients, including hydrocephalus (20) and infarction (11).
- EEG findings significantly correlated with meningitis severity, coma depth, and 3-month Barthel index scores.
Conclusions:
- EEG changes are common in TBM and reflect disease severity.
- EEG findings can predict patient outcomes in TBM.
- Integrating EEG with clinical and radiological data improves prognostic assessment in TBM.