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Time-dependent motor memory processes in amnesic subjects

R Shadmehr1, J Brandt, S Corkin

  • 1Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland 21205-2195, USA.

Journal of Neurophysiology
|September 24, 1998
PubMed
Summary
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Motor memories retain their time-dependent properties even with damage to the declarative memory system. Amnesia patients, including H.M., showed normal motor memory changes over time, suggesting intact procedural memory function.

Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Motor Control

Background:

  • Motor memories exhibit time-dependent changes, similar to declarative memories.
  • The impact of declarative memory damage on motor memory's temporal properties is not well understood.

Purpose of the Study:

  • To investigate if time-dependent properties of motor memories are preserved in individuals with global amnesia.
  • To determine if damage to the declarative memory system affects motor memory consolidation and decay.

Main Methods:

  • Assessed visuomotor adaptation and force field learning in five amnesiac subjects (including H.M.) and age-matched controls.
  • Measured motor memory retention and decay at 5 minutes and 4 hours post-practice.
  • Quantified aftereffects to evaluate the persistence of learned motor memories.

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Main Results:

  • Subject H.M. showed initial impairment in visuomotor transformations but improved with practice.
  • Both amnesiac and control groups demonstrated similar time-dependent patterns of motor memory perseveration and decay.
  • Aftereffects indicating motor memory persistence were comparable between groups at 5 minutes and 4 hours.

Conclusions:

  • The time-dependent properties of motor memory are intact in individuals with global amnesia.
  • Motor memory consolidation and decay processes appear independent of the declarative memory system.
  • Findings suggest that procedural memory, underlying motor skills, operates separately from declarative memory systems.