Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Memory function in aging and Parkinson's disease--an event-related potential study]

Y Miyata1, H Tachibana, M Sugita

  • 1Fifth Department of Internal Medicine, Hyogo College of Medicine.

Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics
|September 24, 1998
PubMed
Summary

Event-related potentials (ERPs) reveal that Parkinson's disease (PD) patients exhibit impaired N400 responses and episodic memory compared to healthy older adults. This suggests significant cognitive decline in PD beyond normal aging.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Japanese Multicenter Study on PET and Other Biomarkers for Subjects with Potential Preclinical and Prodromal Alzheimer's Disease.

The journal of prevention of Alzheimer's disease·2021
Same author

SU-E-T-555: Weighted Four-Dimensional IMRT Planning for Dynamic MLC Tracking Using a Practical and Simple Framework.

Medical physics·2017
Same author

SU-E-J-165: Development of a Low-Cost and Clinically Available Patient Intrafraction Motion Monitoring System.

Medical physics·2017
Same author

Trapping of excess energy in a nano-layered microenvironment to promote chemical reactions.

Physical chemistry chemical physics : PCCP·2017
Same author

FOXO3 is essential for CD44 expression in pancreatic cancer cells.

Oncogene·2016
Same author

Interactions of Dietary Fats and Proteins on Fatty Acid Composition of Immune Cells and LTB4 Production by Peritoneal Exudate Cells of Rats.

Bioscience, biotechnology, and biochemistry·2016

Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Neurology

Context:

  • Investigated event-related potentials (ERPs), specifically the N400 component, in relation to memory processing.
  • Examined differences in N400 amplitude and repetition effects across young healthy adults, older healthy adults, and patients with non-demented Parkinson's disease (PD).

Purpose:

  • To explore how aging and Parkinson's disease affect the N400 response, a marker of semantic processing and memory.
  • To assess episodic memory function using the Rey Auditory Verbal Learning Test (AVLT) in these participant groups.

Summary:

  • Mean N400 amplitude was reduced in PD patients compared to both young and old healthy controls.
  • N400 repetition effects, indicating memory retrieval, were diminished in PD patients, showing attenuation only for immediate repetitions.

Related Experiment Videos

  • Older adults and PD patients showed impaired free recall on the AVLT, with PD patients exhibiting greater deficits and slower learning curves.

    • Impact:

    • Findings suggest that episodic memory declines with age and is further impaired in non-demented Parkinson's disease.
    • The study indicates potential difficulties in transforming information from short-term to long-term memory in PD patients.