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Related Concept Videos

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Related Experiment Videos

Nickel content of standard patch test materials

T Nakada1, J J Hostýnek, H I Maibach

  • 1Department of Dermatology, Showa University School of Medicine, Tokyo, Japan.

Contact Dermatitis
|September 24, 1998
PubMed
Summary
This summary is machine-generated.

Nickel sulfate content in standard patch tests was measured using advanced spectroscopy. Results show improved quality control and consistency in nickel sulfate concentrations across different materials.

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Area of Science:

  • Analytical Chemistry
  • Dermatology
  • Materials Science

Background:

  • Standard patch test materials are crucial for diagnosing nickel allergy.
  • Accurate nickel sulfate concentrations are vital for reliable diagnostic results.
  • Previous assessments indicated variability in nickel content in patch test materials.

Purpose of the Study:

  • To quantify the nickel sulfate content in standard patch test materials used globally.
  • To assess the accuracy and consistency of nickel sulfate concentrations in these materials.
  • To compare current quality control with previously published data.

Main Methods:

  • Inductively-coupled plasma atomic emission spectroscopy (ICP-AES) was employed for precise nickel detection.
  • Analysis was performed on multiple batches of nickel sulfate materials with varying nominal concentrations (5% and 2.5%).
  • Materials included nickel sulfate hexahydrate in petrolatum and aqueous solutions, as well as anhydrous nickel sulfate in petrolatum.

Main Results:

  • Nickel sulfate concentrations in 5% nominal materials ranged from 4.72% to 5.39%.
  • Concentrations in 2.5% nominal materials ranged from 2.39% to 2.48%.
  • The determined values suggest enhanced consistency and quality control compared to prior studies.

Conclusions:

  • Current standard patch test materials demonstrate improved accuracy in nickel sulfate content.
  • Advanced analytical techniques confirm the reliability of nickel concentrations for allergy testing.
  • The findings indicate a positive trend in manufacturing quality control for diagnostic materials.