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Selenium and liver cirrhosis

A Al-Bader1, H Abul, T Hussain

  • 1Department of Pathology, Faculty of Medicine, Kuwait University Health Sciences Centre, Safat.

Molecular and Cellular Biochemistry
|September 24, 1998
PubMed
Summary
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Thioacetamide-induced selenium deficiency in rats caused liver cirrhosis and organ weight changes. Selenium supplementation reversed these effects, suggesting its crucial role in maintaining organ health and potentially involving antioxidant defense.

Area of Science:

  • Biochemistry
  • Toxicology
  • Nutritional Science

Background:

  • Selenium is an essential trace element vital for numerous physiological processes.
  • Thioacetamide is a known hepatotoxin that can induce liver damage.
  • Understanding the specific effects of selenium deficiency is crucial for public health.

Purpose of the Study:

  • To investigate the effects of selenium deficiency induced by thioacetamide in a rat model.
  • To determine the impact of thioacetamide on selenium levels in various organs and plasma.
  • To assess the reversibility of thioacetamide-induced changes through selenium supplementation.

Main Methods:

  • Rats were administered thioacetamide (0.3 g/L) in drinking water.
  • Selenium levels were measured in the liver, spleen, lungs, testis, and kidney.

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  • Organ weights and liver to body weight ratios were recorded.
  • Plasma selenium levels were analyzed.
  • Selenium supplementation was used to reverse observed effects.

    • Main Results:

    • Thioacetamide significantly reduced selenium levels in the liver and spleen.
    • Liver cirrhosis and increased liver weight were observed in thioacetamide-treated rats.
    • Spleen weight increased, while lung, testis, and kidney weights remained unaffected.
    • Plasma selenium levels were significantly decreased.
    • Selenium supplementation successfully reversed all observed thioacetamide-induced changes.

    Conclusions:

    • Thioacetamide effectively induces selenium deficiency, leading to significant liver and spleen alterations in rats.
    • Selenium plays a critical role in maintaining organ integrity, particularly the liver.
    • The findings suggest that selenium's protective effects may involve antioxidant mechanisms, warranting further investigation.