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Related Experiment Videos

A new monofluorinated phosphatidylcholine forms interdigitated bilayers

D J Hirsh1, N Lazaro, L R Wright

  • 1Department of Chemistry, Washington University, St. Louis, Missouri 63130, USA.

Biophysical Journal
|September 24, 1998
PubMed
Summary
This summary is machine-generated.

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Introducing a novel fluorinated phospholipid, F-DPPC, which exhibits a higher phase transition temperature and forms interdigitated bilayers spontaneously. This discovery offers new insights into lipid bilayer formation and dynamics.

Area of Science:

  • Lipid Chemistry
  • Biophysical Chemistry
  • Materials Science

Background:

  • Dipalmitoylphosphatidylcholine (DPPC) is a common phospholipid model.
  • Understanding lipid bilayer formation is crucial for biological and material applications.
  • Fluorinated analogs can alter phospholipid properties.

Purpose of the Study:

  • To synthesize and characterize a novel fluorinated phospholipid, F-DPPC.
  • To investigate the structural and thermal properties of F-DPPC bilayers.
  • To explore the spontaneous formation of interdigitated bilayers.

Main Methods:

  • Synthesis of 16-Fluoropalmitic acid and F-DPPC.
  • Differential Scanning Calorimetry (DSC) and Infrared Spectroscopy.
  • Solid-state NMR (REDOR), Electron Paramagnetic Resonance (EPR), and X-ray scattering.

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Main Results:

  • F-DPPC exhibits a phase transition temperature (Tm) ~10°C higher than DPPC.
  • The pretransition observed in DPPC is absent in F-DPPC.
  • F-DPPC spontaneously forms fully interdigitated bilayers in the gel phase, with restricted chain mobility.

Conclusions:

  • F-DPPC is the first phosphoglyceride with equal-length acyl chains to spontaneously form interdigitated bilayers.
  • Fluorination significantly impacts lipid packing and phase behavior.
  • This provides a new model system for studying interdigitated lipid bilayers without inducing agents.