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Muscle changes in acromegaly

M Nagulesparen, R Trickey, M J Davies

    British Medical Journal
    |October 16, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Acromegaly affects muscle fibers, causing type 1 fiber hypertrophy and type 2 fiber atrophy. Muscle biopsy is key to understanding acromegalic myopathy progression.

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    Area of Science:

    • Endocrinology
    • Neurology
    • Muscle Physiology

    Background:

    • Acromegaly, a disorder caused by excess growth hormone, can lead to various complications.
    • Muscle involvement (myopathy) is a recognized but not fully understood manifestation of acromegaly.

    Purpose of the Study:

    • To investigate the specific changes in muscle fibers in patients with acromegaly.
    • To evaluate the utility of the needle biopsy technique in studying acromegalic myopathy.

    Main Methods:

    • Muscle biopsy specimens were collected from 18 patients diagnosed with acromegaly.
    • Histological examination of muscle fibers was performed to identify hypertrophy or atrophy.
    • Correlation analysis was attempted between muscle morphology and growth hormone levels.

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    Main Results:

    • Half of the muscle biopsy specimens exhibited hypertrophy of type 1 muscle fibers.
    • Atrophy was predominantly observed in type 2 muscle fibers.
    • No direct correlation was found between the observed muscle abnormalities and the severity of growth hormone excess.

    Conclusions:

    • Acromegaly is associated with distinct patterns of muscle fiber alteration, specifically type 1 hypertrophy and type 2 atrophy.
    • The needle biopsy technique is a suitable method for assessing the natural history and progression of acromegalic myopathy.