Cellular and subcellular antioxidants involved in liver susceptibility to xenobiotics

Our previous studies have shown that some important serum erythrocyte and liver antioxidative defense factors--ceruloplasmine, catalase, superoxid dismutase, glutathione -SH and protein-SH groups--were sensitively affected by xenobiotics impact in rat. The data are completed here with the subcellular level of these factors. Dose or time exposure induced appreciable changes of the antioxidative factors (catalase, superoxid dismutase, ceruloplasmine) suggesting their redistribution between the subcellular fractions. The liver morphological investigations in all experimental variants express the aggressivity of Carbofuran administered alone and the "correctional" effects of the modulators' interference.