Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Pruritus and the hepatitis C virus. The MULTIVIRC Unit]

H Dega1, C Francès, N Dupin

  • 1Service de Médecine Interne, Groupe hospitalier Pitié-Salpétrière, Paris.

Annales De Dermatologie Et De Venereologie
|September 25, 1998
PubMed
Summary

Hepatitis C virus (HCV) infection can cause pruritus, or itching, in patients, often presenting as non-specific skin lesions or xerosis. This study highlights that cholestasis doesn't solely explain these symptoms, suggesting other factors related to HCV or its treatments may be involved.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Cutaneous hyperpigmentation, flexion of interphalangeal joints and hallux valgus in a 42 year-old patient].

La Revue de medecine interne·2022
Same author

Performance accuracy, advantages and limitations of a store-and-forward teledermatology platform developed for general practitioners: A retrospective study of 298 cases.

Annales de dermatologie et de venereologie·2022
Same author

Antiphospholipid-negative Sneddon's syndrome: A comprehensive overview of a rare entity.

Annales de dermatologie et de venereologie·2021
Same author

Cutaneous drug-induced lupus erythematosus: Clinical and immunological characteristics and update on new associated drugs.

Annales de dermatologie et de venereologie·2021
Same author

Intravenous immunoglobulins: an eye opener on the successful treatment of severe adult-onset paraprotein-associated xanthogranulomatosis.

Clinical and experimental dermatology·2021
Same author

Combined Methotrexate and Alitretinoin for the treatment of difficult-to-treat generalized prurigo nodularis: a case series.

Journal of the European Academy of Dermatology and Venereology : JEADV·2021

Area of Science:

  • Hepatology and Dermatology
  • Viral Hepatitis Research
  • Clinical Manifestations of HCV

Context:

  • Hepatitis C virus (HCV) infection is a significant global health concern.
  • Pruritus is a common yet often poorly understood symptom in patients with chronic liver diseases.
  • Understanding pruritus characteristics in HCV patients is crucial for effective management.

Purpose:

  • To determine the clinical characteristics of pruritus in patients with confirmed hepatitis C virus serology.
  • To investigate potential associations between pruritus and disease severity, liver function, and HCV markers.
  • To explore the spectrum of dermatological manifestations associated with pruritus in this cohort.

Summary:

  • A retrospective analysis of 27 patients with HCV and pruritus revealed non-specific excoriations, prurigo, or xerosis in 70% of cases.

Related Experiment Videos

  • Pruritus duration varied, with a median of 3 months; 41% presented with eczema-like lesions.
  • Elevated liver enzymes (ALAT, gamma GT) were observed, but 11 patients had normal gamma GT, indicating cholestasis is not the sole cause. Cryoglobulinemia was present in 10/24 patients, and HCV RNA PCR was positive in 13/15.

    • Impact:

    • This study underscores that pruritus in HCV patients is multifactorial, potentially linked to direct viral effects or treatments like interferon.
    • The findings suggest that pruritus management in HCV may require addressing factors beyond cholestasis.
    • Further prospective research is recommended to fully elucidate the frequency, risk factors, and quality of life impact of pruritus in HCV.