[Cutaneous manifestations during disseminated trichosporonosis in an AIDS patient]

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A S Lascaux1, F Bouscarat, V Descamps

  • 1Service de Dermatologie, Hôpital Bichat, Paris.

Annales De Dermatologie Et De Venereologie
|September 25, 1998
PubMed
Abstract

Insights

Disseminated Trichosporon beigelii infection, a rare fungal disease, can affect immunocompromised individuals. Early diagnosis and treatment with amphotericin B are crucial for favorable outcomes, even in HIV patients without neutropenia.

Area of Science:

  • Mycology
  • Infectious Diseases
  • Clinical Medicine

Background:

  • Trichosporon beigelii, the cause of white piedra, can lead to disseminated infections, particularly in immunocompromised individuals.
  • Systemic infections are predominantly observed in neutropenic patients and less frequently in those with Acquired Immunodeficiency Syndrome (AIDS).

Observation:

  • A 36-year-old HIV-positive male presented with fever, meningoencephalitis, and skin lesions.
  • Trichosporon beigelii was identified in skin biopsies and cerebrospinal fluid, confirming disseminated infection.

Findings:

  • The patient received amphotericin B, resulting in the regression of skin lesions.
  • The absence of neutropenia in this patient likely contributed to the favorable response to antifungal therapy.

Implications:

  • Disseminated T. beigelii infections necessitate prompt diagnosis and treatment, even in non-neutropenic HIV patients.
  • Skin biopsies and cultures are vital for rapid diagnosis and guiding appropriate antifungal strategies.
  • This case highlights the importance of considering disseminated fungal infections in immunocompromised patients presenting with systemic symptoms and skin manifestations.

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