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Patch testing for Compositae allergy

V Goulden1, S M Wilkinson

  • 1Department of Dermatology, Leeds General Infirmary, U.K.

The British Journal of Dermatology
|September 25, 1998
PubMed
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Standard sesquiterpene lactone (SL) mix misses nearly 40% of Compositae allergies. Testing with additional Compositae extracts like dandelion and feverfew significantly improves detection rates in allergic patients.

Area of Science:

  • Dermatology
  • Allergology
  • Plant Science

Background:

  • Sesquiterpene lactones (SLs) are primary allergens in Compositae plants.
  • A standard mix of three SLs is commonly used for Compositae allergy testing.
  • This standard mix may not identify all individuals sensitive to Compositae plants.

Purpose of the Study:

  • To evaluate the diagnostic value of testing with a broader range of Compositae extracts.
  • To determine the effectiveness of the standard SL mix versus individual Compositae extracts.
  • To identify optimal allergen panels for diagnosing Compositae allergy.

Main Methods:

  • Patch testing 97 patients with suspected Compositae allergy (dermatitis/hand eczema, gardening exposure).
  • Utilized European standard series, SL mix (0.1% pet.), Compositae extracts (dandelion, feverfew), and other allergens.

Related Experiment Videos

  • Analyzed allergic reactions to SL mix and specific Compositae extracts.

    • Main Results:

    • 26% of patients showed allergic reactions to SL mix or Compositae extracts.
    • The standard SL mix failed to detect 38% of Compositae-sensitive patients.
    • Dandelion and feverfew extracts identified additional allergic patients missed by the SL mix, with dandelion detecting 73% and combined dandelion/feverfew detecting 91% of SL mix-negative cases.

    Conclusions:

    • The standard SL mix is insufficient for diagnosing all cases of Compositae allergy.
    • Testing with additional Compositae extracts, such as dandelion and feverfew, is crucial for patients with suspected allergy.
    • A comprehensive approach using multiple Compositae extracts improves diagnostic accuracy for Compositae-induced allergic contact dermatitis.