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Antimycobacterial evaluation of germacranolides
N H Fischer1, T Lu, C L Cantrell
1Department of Chemistry, Louisiana State University, Baton Rouge 70803-1804, USA. fischer@chemgate.chem.lsu.edu
Phytochemistry
|September 25, 1998
Abstract:
The minimum inhibitory concentrations (MIC) against Mycobacterium tuberculosis and M. avium of parthenolide, costunolide, 1 (10)-epoxycostunolide and other germacranolide-type sesquiterpene lactones and derivatives were determined by use of a radiorespirometric bioassay. Structure-activity relationship studies with natural and semisynthetic sesquiterpene lactones suggested that the alpha-methylene-gamma-lactone moiety is an essential, but not sufficient, structural requirement for significant in vitro activity against M. tuberculosis and M. avium.