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Ascorbic acid clearance in diabetic nephropathy

I B Hirsch1, D H Atchley, E Tsai

  • 1Department of Medicine, University of Washington, Seattle, USA.

Journal of Diabetes and Its Complications
|September 25, 1998
PubMed
Summary

Diabetic nephropathy patients show reduced vitamin C levels due to increased ascorbic acid clearance by the kidneys. This decline in antioxidant defense may worsen cardiovascular outcomes in diabetes.

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Area of Science:

  • Nephrology
  • Endocrinology
  • Nutritional Science

Background:

  • Diabetic nephropathy is linked to increased cardiovascular disease risk.
  • Oxidative stress and reduced antioxidant vitamins, like ascorbic acid, are implicated in diabetic atherosclerosis.
  • Ascorbic acid (vitamin C) levels are often diminished in diabetic patients.

Purpose of the Study:

  • To investigate the relationship between diabetic nephropathy and ascorbic acid levels.
  • To determine if increased renal clearance of ascorbic acid contributes to lower vitamin C levels in diabetic nephropathy patients.

Main Methods:

  • Studied 37 patients with diabetic nephropathy, categorized by microalbuminuria and clinical nephropathy.
  • Measured glycemic control (glucose, HbA1C), renal function (albuminuria, creatinine clearance), and serum/urinary ascorbic acid levels.

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Main Results:

  • Patients with clinical nephropathy had lower plasma ascorbic acid and higher renal clearance compared to those with microalbuminuria.
  • Found an inverse correlation between creatinine clearance and ascorbic acid clearance.
  • Observed a significant association between albuminuria quantity and ascorbic acid clearance.

Conclusions:

  • Diabetic nephropathy is associated with reduced ascorbic acid levels, primarily due to increased renal clearance.
  • Decreased vitamin C levels may compromise antioxidant defenses, potentially contributing to cardiovascular complications in this population.