Candida is not involved in the development of of periungual psoriatic lesion

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Updated: Oct 28, 2026

Examination of Oral Candida Infection in Primary Sjögren's Syndrome Patients
05:26

Examination of Oral Candida Infection in Primary Sjögren's Syndrome Patients

Published on: March 1, 2024

H Miura1, S Sano, M Higashiyama

  • 1Department of Dermatology, Osaka University, School of Medicine, Japan.

Journal of Dermatological Science
|September 25, 1998
PubMed

Insights

This study investigated if Candida infection contributes to psoriasis in fingernail areas. Researchers found no evidence linking local Candida infections to psoriatic changes in the periungual region.

Area of Science:

  • Dermatology
  • Infectious Diseases
  • Immunology

Background:

  • Infections, particularly bacterial, are known to trigger or worsen psoriasis, potentially via superantigens.
  • Fungi, including Candida, can also produce superantigens.
  • Periungual (around the nails) lesions are common in psoriasis patients.

Purpose of the Study:

  • To investigate the potential pathogenetic role of local Candida infection in the periungual lesions of psoriatic patients.
  • To determine if Candida infection exacerbates psoriasis in the periungual area.

Main Methods:

  • Microscopic examination of periungual lesions in 15 psoriatic patients.
  • Fungal culture to detect Candida presence.
  • Assessment of response to antifungal treatment.

Main Results:

  • No evidence was found to suggest a relationship between Candida infection and psoriatic changes in the periungual area.
  • Microscopic studies and cultures did not reveal a significant link.

Conclusions:

  • Local Candida infection does not appear to play a significant pathogenetic role in the periungual lesions of psoriasis.
  • Further research may be needed to fully understand the role of fungal infections in psoriasis exacerbation.

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