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Response plasticity in hamster olfactory bulb: peripheral and central processes

H Potter, S L Chorover

    Brain Research
    |November 12, 1976
    PubMed
    Summary
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    Sensory adaptation occurs in both olfactory receptors and central brain structures. This study reveals stimulus-specific habituation in the olfactory bulb, suggesting neural plasticity independent of centrifugal inputs.

    Area of Science:

    • Neuroscience
    • Olfactory system research
    • Sensory adaptation mechanisms

    Background:

    • Prolonged odor stimulation is known to cause significant sensory adaptation.
    • Electrophysiological changes occur at both olfactory receptors and central olfactory structures during adaptation.

    Purpose of the Study:

    • To investigate electrophysiological phenomena during prolonged odor stimulation.
    • To compare olfactory receptor and olfactory bulb responses to repeated odor exposure.
    • To explore the role of centrifugal inputs in olfactory bulb habituation.

    Main Methods:

    • Recorded electro-olfactogram (EOG) for olfactory receptor response.
    • Recorded olfactory bulb unit responses (mitral cells) during repeated odor stimulation.
    • Utilized surgical disconnection of olfactory bulb centrifugal inputs in some preparations.

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    Main Results:

    • Response decrements in EOG during continuous odor presentation were mirrored in olfactory bulb mitral cells.
    • Olfactory receptor responsiveness rebounded after brief rest periods, but mitral cell responses did not.
    • Surgical disconnection led to hyperactive mitral cells with faster habituation and longer recovery times.
    • Mitral cell synchronization to inhalation cycle was reduced after surgical disconnection.

    Conclusions:

    • Olfactory bulb response decrement suggests stimulus-specific habituation, a model for neural plasticity.
    • Mitral cell habituation is not dependent on centrifugal inputs.
    • Centrifugal inputs modulate and tune mitral cell response characteristics in an inhibitory manner.