Related Experiment Videos
Lewy body in neurodegeneration with brain iron accumulation type 1 is immunoreactive for alpha-synuclein
S Arawaka1, Y Saito, S Murayama
1Department of Molecular Biology, Tokyo Institute of Psychiatry, Japan.
Neurology
|September 25, 1998
Abstract:
In familial PD, a mutation of the alpha-synuclein gene has been identified. Alpha-synuclein also was revealed in Lewy bodies in idiopathic PD. Lewy bodies in neurodegeneration with brain iron accumulation type 1 (NBIA 1; Hallervorden-Spatz syndrome) were found to show immunostaining for alpha-synuclein/precursor of non-A beta component of Alzheimer's disease amyloid, indicating that alpha-synuclein is commonly associated with the formation of Lewy bodies in other sporadic and familial neurodegenerative diseases apart from PD.