Effects of age and ethanol on dopamine and serotonin release in the rat nucleus accumbens

¹Department of Legal Medicine, Kyoto Prefectural University of Medicine, Japan.

|September 25, 1998

Abstract:

Neural functions in the nucleus accumbens (ACC) play an important role in alcohol drinking behavior. In the present study, we observed the effects of age and ethanol (EtOH) on dopamine (DA) and serotonin (5-HT) release in the ACC of freely moving 4-, 10-, and 16-month-old rats using brain microdialysis techniques. After co-perfusion with 200 mM ethanol, ACC DA, and 5-HT release were decreased significantly in 16-month-old rats compared to those at 4 months old. ACC DA and 5-HT neurons of aged rats were less sensitive to ethanol. On the other hand, both basal extracellular DA and 5-HT release in the ACC were significantly higher in 16-month-old than in 4-month-old rats. Therefore, aging results in opposite changes in basal and alcohol-induced DA and 5-HT release in the ACC.

Related Experiment Videos

Effects of age and ethanol on dopamine and serotonin release in the rat nucleus accumbens

Related Concept Videos

[Spinal intradural arachnoid cyst associated with enlarged filum terminale].

[A case of systemic lupus erythematosus associated with cerebral infarction and cerebral hemorrhage].

[A case of growing up aneurysms with occlusion of basilar artery].

Expression and biological activities of bovine interleukin 4: effects of recombinant bovine interleukin 4 on T cell proliferation and B cell differentiation and proliferation in vitro.

Craniofacial deformities associated with juvenile hyperthyroidism.

[Subdural abscess following chronic subdural hematoma].

Maternal high-fat diet and metformin treatment affect palatable diet preference and central reward system gene expression in rat offspring in a sex-specific manner.

The effect of concurrent application of the deep brain stimulation of the nucleus accumbens and cannabidiol injection during extinction period on reinstatement of METH-induced conditioned place preference in extinguished rats.

Openness to experience modulates the neural dynamics of semantic processing.

Intermittent Fasting as a Therapeutic Strategy in Alzheimer's Disease: Understanding of Brain-Derived Neurotrophic Factor Modulation.

Distinct behavioral and electrophysiological correlates of sleep disturbance during verbal and spatial working memory tasks.

Exploring the reconfiguration effects of physical fatigue on the gradient space of brain function based on EEG.

Benchmarking Generative AI and Physics-Based Molecular Simulation for Sampling Conformational Heterogeneity in T4 Lysozyme.

A Simulation-Free Topological Basis for Building Compact Koopman Models of Protein Folding.

Taming Mre11-Rad50 at Telomeres: Convergent Strategies for Chromosome-End Protection Across Evolution.

Functional Adaptations for Load-Bearing in a Dermal Bone: The Pectoral Fin Spine of the Russian Sturgeon (Huso Gueldenstaedtii).

Age distribution of inoculated cells and stochasticity of inter-division times generate pseudo-lag in population growth.

Bridging spatial scales in respiratory viral infection.

Related Experiment Videos

Effects of age and ethanol on dopamine and serotonin release in the rat nucleus accumbens

Abstract:

Related Concept Videos

Related Articles