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Antimalarial principles from Artemisia indica
R Chanphen1, Y Thebtaranonth, S Wanauppathamkul
1National Center for Genetic Engineering and Biotechnology (BIOTEC)/National Science and Technology Development Agency (NSTDA), Rama 6 Road, Bangkok 10400, Thailand.
Journal of Natural Products
|September 28, 1998
Summary
Activity-guided research on Artemisia indica Willd. isolated four compounds, including exiguaflavones A and B. These compounds demonstrated in vitro antimalarial activity against Plasmodium falciparum.
Area of Science:
- Natural Product Chemistry
- Pharmacology
- Medicinal Chemistry
Background:
- Artemisia indica Willd. is a plant with a history of traditional medicinal use.
- Identifying bioactive compounds from medicinal plants is crucial for drug discovery.
- Plasmodium falciparum is a parasite responsible for severe malaria.
Purpose of the Study:
- To isolate and identify bioactive compounds from Artemisia indica Willd.
- To evaluate the in vitro antimalarial activity of the isolated compounds.
Main Methods:
- Activity-guided fractionation of Artemisia indica Willd. extract.
- Isolation and structural elucidation of compounds using spectroscopic methods.
- In vitro antimalarial assays against Plasmodium falciparum.
Main Results:
- Four compounds were isolated: exiguaflavone A, exiguaflavone B, maackiain, and 2-(2, 4-dihydroxyphenyl)-5,6-methylenedioxybenzofuran.
- Exiguaflavone A showed an IC50 of 4.60 x 10(-6) g/mL against Plasmodium falciparum.
- Exiguaflavone B exhibited an IC50 of 7.05 x 10(-6) g/mL against Plasmodium falciparum.
Conclusions:
- Artemisia indica Willd. contains compounds with significant in vitro antimalarial activity.
- Exiguaflavones A and B are promising leads for the development of new antimalarial drugs.