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Inhibition of long-term potentiation in developing rat visual cortex but not hippocampus by in utero exposure to
L Altmann1, H Lilienthal, J Hany
1Medical Institute of Environmental Hygiene, Heinrich-Heine-Univ. Düsseldorf, Department of Neurotoxicology, Auf'm Hennekamp 50, D-40225, Düsseldorf, Germany. altmannl@rz.uni-duesseldorf.de
Brain Research. Developmental Brain Research
|September 28, 1998
Abstract:
The neurotoxic potential of polychlorinated biphenyls (PCBs) depends on the structure of the congener as well as on the age of the exposure. We exposed rats prenatally to a coplanar congener (PCB-77) or to a non-coplanar congener (PCB-47) and measured the amount of long-term potentiation (LTP) at postnatal days 11-19 in the visual cortex and hippocampus. While PCB-77 exposure affected LTP statistically significantly in cortical but not hippocampal slices, the exposure to PCB-47 was much less effective.