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High performance liquid chromatographic method for the determination of lobenzarit disodium in a sustained release
A Paneque1, A I Torres, M A Camacho
1Center of Pharmaceutical Chemistry, Havana, Cuba.
Arzneimittel-Forschung
|September 28, 1998
Abstract:
A rapid and simple high performance liquid chromatographic method is described and validated for the determination of lobenzarit disodium (CAS 64808-48-6) in a sustained release tablet formulation. The calibration graph was linear over the range 20-105 micrograms/ml. The sensitivity (discriminator capacity) was 2.079 micrograms/ml. The coefficient of variations for repeatability and reproducibility were less than 1.60% and 1.30%, respectively. The accuracy of the method did not depend on lobenzarit concentration in tablets. The mean recovery was found to be 100.62%. The method was selective, even when degradation products were present.