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[Familial hemiplegic migraine]

L L Thomsen1, J Olesen, M B Russell

  • 1Neurologisk afdeling, Amtssygehuset i Glostrup.

Ugeskrift for Laeger
|September 28, 1998
PubMed
Summary
This summary is machine-generated.

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Familial hemiplegic migraine (FHM) is a rare, inherited neurological disorder. Genetic studies reveal FHM is caused by mutations in at least three different genes affecting ion channels.

Area of Science:

  • Neurology
  • Genetics
  • Molecular Biology

Context:

  • Familial hemiplegic migraine (FHM) is a rare subtype of migraine with aura.
  • It is inherited as an autosomal dominant trait.
  • FHM exhibits genetic heterogeneity, involving mutations in ion channel genes.

Purpose:

  • To investigate the genetic basis of Familial hemiplegic migraine (FHM).
  • To identify the genes responsible for FHM and related neurological disorders.

Summary:

  • A gene for FHM has been mapped to chromosome 19, coding for a brain-specific calcium channel, accounting for 55% of FHM families.
  • Other FHM families are linked to chromosome 1, with candidate genes for calcium and potassium channels.
  • Approximately 29% of FHM families also exhibit cerebellar ataxia, linked to chromosome 19.

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Impact:

  • Identification of FHM genes provides insight into the genetic underpinnings of migraine with and without aura.
  • Understanding FHM's genetic heterogeneity aids in diagnosing and potentially treating migraine subtypes.
  • This research highlights the role of ion channel dysfunction in neurological disorders.